The big stampede for hotel rooms for this year's Comic-Con International is happening day after tomorrow. It starts at 9 AM Pacific Daylight Time on April 24, 2025 and if things go like they have in past years, the room you want will be booked by someone else by 9:30.
I have no idea why they aren't doing this on a Saturday like they usually do. Matter of fact, I really don't know much about this at all so I'll just direct you to this page and wish you luck.