As you may know, the San Diego Padres play at Petco Park, which is right next to the convention center where the Comic-Con is held. They put it there because they thought the traffic and parking weren't quite bad enough when we're in town. (But hey, it would be worse in L.A., next door to the Staples Center.)
The Padres are away from S.D. the week of Comic-Con. They'll be in Atlanta and Pittsburgh, which should be about where the nearest vacant hotel rooms will be available. However, the Friday night before the con — July 16 — the Padres are playing the Arizona Diamondbacks at Petco Park and they're advertising it's Comic-Con Night. Douglass Abramson, a devout reader of this site, told me about it and he doesn't know what it means, either. Maybe all the players on one team will be dressed as Klingons and all the ones on the other will be dressed as The Joker and for the seventh-inning stretch, I'll go down onto the field and host a panel.