The good folks at Operation USA have been sending vital aid to Haiti…and now they're already sending supplies and medical assistance to Chile.
Not to disparage any other charitable effort but I've been following and supporting Operation USA for some time and I've met several of its officers. You can't get a better return on your donations than you'll get when you send them money. The absolute minimum goes to administrative costs and further fund-raising. The absolute maximum goes to helping people who really need help.